Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos
Summary: Assisted reproductive technology has been widely applied in the treatment of human infertility.However, accumulating evidence indicates that in vitro fertilization (IVF) is associated with a low pregnancy rate, placental defects, and metabolic diseases in offspring.Here, we find that IVF manipulation notably disrupts extraembryonic tissue-